abstract：:Astrocytes are major components of the adult neurogenic niche and play a crucial role in regulating neural stem cell proliferation and differentiation. Following brain injury, astrocytes become reactive and release high-mobility group box 1 (HMGB1), which plays a crucial role in the inflammatory process. However, alth...

journal_title：International journal of molecular medicine

authors： Li M,Sun L,Luo Y,Xie C,Pang Y,Li Y

更新日期：2014-09-01 00:00:00

abstract：:Numerous studies have demonstrated the antioxidant effects of grape seed proanthocyanidin extract (GSPE). The generation of free radicals and the ensuing apoptosis may contribute to the pathogenesis of epilepsy; therefore, in the present study, we examined the effects of GSPE on cognitive impairment and neuronal damag...

journal_title：International journal of molecular medicine

authors： Zhen J,Qu Z,Fang H,Fu L,Wu Y,Wang H,Zang H,Wang W

更新日期：2014-08-01 00:00:00

abstract：:Cardiac fibroblast (CF) proliferation and transformation into myofibroblasts play important roles in cardiac fibrosis during pathological myocardial remodeling. In this study, we demonstrate that hepatocyte growth factor (HGF), an antifibrotic factor in the process of pulmonary, renal and liver fibrosis, is a negative...

journal_title：International journal of molecular medicine

authors： Yi X,Li X,Zhou Y,Ren S,Wan W,Feng G,Jiang X

更新日期：2014-08-01 00:00:00

abstract：:The introduction of bortezomib has resulted in a paradigm shift in the treatment of multiple myeloma (MM) and has contributed to the improved survival of patients with MM. Inevitably, resistance to therapy develops, and thus the clinical efficacy of bortezomib is hampered by drug resistance. The oncogene B-cell‑specif...

journal_title：International journal of molecular medicine

authors： Wu SQ,Xu ZZ,Niu WY,Huang HB,Zhan R

更新日期：2014-08-01 00:00:00

abstract：:POU domain proteins are a family of critical regulators of development and differentiation due to their transcriptional activity in the nucleus. Skn‑1a, a member of the POU domain protein family, appears to be expressed predominantly in epidermal keratinocytes and is thought to play a critical role in keratinocyte dif...

journal_title：International journal of molecular medicine

authors： Moritsugu R,Tamai K,Nakano H,Aizu T,Nakajima K,Yamazaki T,Sawamura D

更新日期：2014-08-01 00:00:00

abstract：:Cardiac hypertrophy is a major cause of morbidity and mortality worldwide. Transforming growth factor-β1 (TGF-β1) signaling has been considered as a trigger causally contributing to pathological cardiac hypertrophy. Asiatic acid (AA) is a triterpenoid compound extracted from Centella asiatica and exhibits a variety of...

journal_title：International journal of molecular medicine

authors： Si L,Xu J,Yi C,Xu X,Wang F,Gu W,Zhang Y,Wang X

更新日期：2014-08-01 00:00:00

abstract：:Motility is a requirement for a number of biological processes, including embryonic development, neuronal development, immune responses, cancer progression and wound healing. Specific to wound healing is the migration of endothelial cells, fibroblasts and other key cellular players into the wound space. Aberrations in...

journal_title：International journal of molecular medicine

authors： Bosanquet DC,Ye L,Harding KG,Jiang WG

更新日期：2014-07-01 00:00:00

abstract：:Decreased skeletal muscle capillarization is considered to significantly contribute to the development of pulmonary cachexia syndrome (PCS) and progressive muscle wasting in several chronic inflammatory diseases, including chronic obstructive pulmonary disease (COPD). It is unclear to which extent the concurrent prese...

journal_title：International journal of molecular medicine

authors： Basic VT,Jacobsen A,Sirsjö A,Abdel-Halim SM

更新日期：2014-07-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC), which is estrogen receptor (ER)-negative, progesterone receptor‑negative and is also negative for HER2 expression, remains a great clinical challenge due to its strong resistance to chemotherapy at the late stage of treatment and relatively unfavorable prognosis. Gemcitabine has b...

journal_title：International journal of molecular medicine

authors： Chen M,He M,Song Y,Chen L,Xiao P,Wan X,Dai F,Shen P

更新日期：2014-07-01 00:00:00

abstract：:Musk has been traditionally used in East Asia to alleviate the symptoms of angina pectoris. However, it remains unclear as to whether muscone, the main active ingredient of musk, has any beneficial effects on persistent myocardial ischemia in vivo. The aim of the present study was to investigate whether muscone can im...

journal_title：International journal of molecular medicine

authors： Wang X,Meng H,Chen P,Yang N,Lu X,Wang ZM,Gao W,Zhou N,Zhang M,Xu Z,Chen B,Tao Z,Wang L,Yang Z,Zhu T

更新日期：2014-07-01 00:00:00

abstract：:Lately, the importance of the communication between different cell types and the understanding of the cell communication pathway has been emphasized, as it may provide a novel therapeutic strategy for the regeneration of damaged tissue. In the present study, we suggest that sonic hedgehog (Shh) is a mediator of cell c...

journal_title：International journal of molecular medicine

authors： Kim WJ,Lee SW,Kim KW

更新日期：2014-07-01 00:00:00

abstract：:Colon cancer stem cells (CCSCs) are involved in colon cancer and promote tumor progression and recurrence. LGR5, a marker for intestinal stem cells (ISCs), is also considered to serve as a marker for CCSCs. However, the precise function of LGR5 in CCSCs is unclear. In this study, we demonstrated that LGR5 was highly e...

journal_title：International journal of molecular medicine

authors： Chen X,Wei B,Han X,Zheng Z,Huang J,Liu J,Huang Y,Wei H

更新日期：2014-07-01 00:00:00

abstract：:The volatile anesthetic, sevoflurane, is widely used in surgery. Over the years, there has been a growing interest in the biological effects of sevoflurane on tissue and organ systems and the molecular mechanisms involved. MicroRNAs (miRNAs or miRs) acting as pivotal post‑transcriptional regulators for fine-tuning gen...

journal_title：International journal of molecular medicine

authors： Takeuchi J,Sakamoto A,Takizawa T

更新日期：2014-07-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) of lens epithelial cells (LECs) is the major pathological mechanism in anterior subcapsular cataract (ASC) and posterior capsule opacification (PCO), which are important causes of visual impairment. Extracellular signal-regulated kinase (ERK)1/2 pathway has been reported to play...

journal_title：International journal of molecular medicine

authors： Chen X,Ye S,Xiao W,Wang W,Luo L,Liu Y

更新日期：2014-06-01 00:00:00

abstract：:The transcription factor, forkhead box protein M1 (FoxM1), and the tyrosine kinase receptor, human epidermal growth factor receptor-2 (Her-2), are aberrantly expressed in a number of human malignancies, and are closely associated with the development of cancer. However, their regulatory mechanisms and their involvemen...

journal_title：International journal of molecular medicine

authors： Qi W,Li X,Zhang Y,Yao R,Qiu W,Tang D,Liang J

更新日期：2014-06-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a key coordinator of gene programs in metabolism and energy homeostasis in mammals. The aim of this study was to determine whether PGC-1α is involved in the transcriptional regulation of retinal neovascularization in oxygen-induced retinopathy (OI...

journal_title：International journal of molecular medicine

authors： Zhang L,Jiang J,Xia X

更新日期：2014-06-01 00:00:00

abstract：:The aim of the present study was to investigate the biological activity of 20 essential oils (EOs) derived from herbal plants and citrus fruits. The in vitro anti-allergic and anti-inflammatory activities of these oils were investigated, and the EO which was found to have the strongest activity of the 20 EOs examined,...

journal_title：International journal of molecular medicine

authors： Mitoshi M,Kuriyama I,Nakayama H,Miyazato H,Sugimoto K,Kobayashi Y,Jippo T,Kuramochi K,Yoshida H,Mizushina Y

更新日期：2014-06-01 00:00:00

abstract：:Icariin (ICA) and icaritin (ICT), with a similar structure to genistein, are the important bioactive components of the genus Epimedium, and regulate many cellular processes. In the present study, using the estrogen receptor (ER)-negative breast cancer cell line, SKBr3, as a model, we examined the hypothesis that ICA a...

journal_title：International journal of molecular medicine

authors： Ma HR,Wang J,Chen YF,Chen H,Wang WS,Aisa HA

更新日期：2014-06-01 00:00:00

abstract：:The thymus is the primary site for T-cell lympho-poiesis. Its function includes the maturation and selection of antigen specific T cells and selective release of these cells to the periphery. These highly complex processes require precise parenchymal organization and compartmentation where a plethora of signalling pat...

journal_title：International journal of molecular medicine

authors： Mignini F,Sabbatini M,Mattioli L,Cosenza M,Artico M,Cavallotti C

更新日期：2014-06-01 00:00:00

abstract：:Tumor necrosis factor-α (TNF-α) has been suggested to be a putative tumor promoter gene, and autocrine of TNF-α expression has been found in colon cancer and ovarian cancer. As the role of autocrine TNF-α in human gallbladder cancer has not yet been elucidated, the present study examined the expression of TNF-α in gal...

journal_title：International journal of molecular medicine

authors： Zhu G,Du Q,Wang X,Tang N,She F,Chen Y

更新日期：2014-06-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a disease of unknown etiology with considerable morbidity and mortality. Seeking informative diagnostic markers with greater clinical significance is essential for the early diagnosis of IPF. microRNAs (miRNAs or miRs) have emerged as novel serum diagnostic biomarkers for various...

journal_title：International journal of molecular medicine

authors： Li P,Li J,Chen T,Wang H,Chu H,Chang J,Zang W,Wang Y,Ma Y,Du Y,Zhao G,Zhang G

更新日期：2014-06-01 00:00:00

abstract：:Studies have shown that an overproduction of mitochondrial reactive oxygen species (ROS) is an initiating cause in the pathogenesis of diabetic complications. However, uncoupling protein 2 (UCP2) can protect retinal vascular endothelial cells from damage by inhibiting the overproduction of mitochondrial ROS, although ...

journal_title：International journal of molecular medicine

authors： He Y,Wang N,Shen Y,Zheng Z,Xu X

更新日期：2014-05-01 00:00:00

abstract：:The inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene not only results in tumor initiation, but also mediates tumor metastasis. However, the mechanisms by which VHL inactivation leads to metastasis have not yet been well defined. In this study, the silencing of VHL in 3AO and SKOV3 ovarian cancer cells...

journal_title：International journal of molecular medicine

authors： Liu T,Zhao L,Chen W,Li Z,Hou H,Ding L,Li X

更新日期：2014-05-01 00:00:00

abstract：:As a DNA repair protein, flap endonuclease 1 (FEN1), a structure-specific 5' nuclease, plays pivotal roles in the maturation of Okazaki fragments, long-patch base excision repair, restarting of stalled replication forks and telomere maintenance. FEN1 possesses 5' endonuclease, 5' exonuclease and gap-endonuclease activ...

journal_title：International journal of molecular medicine

authors： Wang K,Xie C,Chen D

更新日期：2014-05-01 00:00:00

abstract：:microRNAs (miRNAs) are important both in early cardiogenesis and in the process of heart maturation. The aim of this study was to determine the stage-specific expression of miRNAs in human fetal heart in order to identify valuable targets for further study of heart defects. Affymetrix microarrays were used to obtain m...

journal_title：International journal of molecular medicine

authors： Zhou J,Dong X,Zhou Q,Wang H,Qian Y,Tian W,Ma D,Li X

更新日期：2014-05-01 00:00:00

abstract：:Biologic abnormalities in vascular smooth muscle cells (VSMC) may perform a crucial role in the pathogenesis of diabetic vascular disease. The principal aim of this study was to determine the effects of zipper-interacting protein kinase (ZIPK) on human aortic smooth muscle cells (HASMCs) stimulated by high glucose (HG...

journal_title：International journal of molecular medicine

authors： Ye Z,Wu W,He M,Leong M,Hu R,Li Y,Zhang S

更新日期：2014-05-01 00:00:00

abstract：:Post-transcriptional control of mRNA trafficking and metabolism plays a critical role in the actualization and fine tuning of the genetic program of cells, both in development and in differentiated tissues. Cis-acting signals, responsible for post-transcriptional regulation, reside in the RNA message itself, usually i...

journal_title：International journal of molecular medicine

authors： Di Liegro CM,Schiera G,Di Liegro I

更新日期：2014-04-01 00:00:00

abstract：:Airway remodeling is characterized by airway wall thickening, subepithelial fibrosis, increased smooth muscle mass, angiogenesis and increased mucus secretion, which can lead to chronic and obstinate asthma and can obstruct pulmonary function. In this study, the effects of Bangpungtongseong-san water extract (BPTS) on ...

journal_title：International journal of molecular medicine

authors： Lee MY,Shin IS,Jeon WY,Shin N,Shin HK

更新日期：2014-04-01 00:00:00

abstract：:Lysophosphatidic acid (LPA) the simplest of the water-soluble phospholipids, is produced by activated platelets, macrophage and endothelial cells. It also evokes various biological responses. When LPA concentrations reach high levels, brain injury, including stroke and intracerebral hemorrhage (ICH), occurs. Previous ...

journal_title：International journal of molecular medicine

authors： Yu Y,Qin J,Liu M,Ruan Q,Li Y,Zhang Z

更新日期：2014-03-01 00:00:00

abstract：:The underground parts of Nardostachys chinensis (N. chinensis), which belongs the genus Valerianaceae, have been used as sedative and analgesic agents in traditional Korean medicine for centuries. The mitogen-activated protein kinases (MAPKs) are serine/threonine kinases involved in the regulation of various cellular ...

journal_title：International journal of molecular medicine

authors： Ju SM,Kang JG,Pae HO,Lee GS,Kim WS,Lyu YS,Jeon BH

更新日期：2014-03-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease with unknown etiology and undefined treatment modality. Fibroblasts are regarded as the major cell type that mediates the onset and progression of lung fibrosis by secreting large amounts of extracellular matrix (ECM) proteins, ...

journal_title：International journal of molecular medicine

authors： Zhang L,Li Y,Liang C,Yang W

更新日期：2014-02-01 00:00:00

abstract：:We have previously reported that the EVn-50 mixture of vitexins (lignan compounds) containing the purified vitexin (neolignan) compound, 6-hydroxy-4(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl‑7-methoxy-3,4-dihydro-2-naphthaldehyde, termed VB1, exhibits potent anticancer activity through the induction of apoptosis in s...

journal_title：International journal of molecular medicine

authors： Liu LH,Zhou YJ,Ding L,Zhang SZ,Sun J,Cao JG

更新日期：2014-02-01 00:00:00

abstract：:Retinoic acid (RA) analogs have been used in the treatment of a variety of cancers; however, their application is limited due to serious therapy-related sequelae. In the present study, the effects of a novel RA analog, 4-amino-2-trifluoromethyl-phenyl retinate (ATPR), on the growth of gastric cancer cells were evaluat...

journal_title：International journal of molecular medicine

authors： Hu KW,Pan XH,Chen FH,Qin R,Wu LM,Zhu HG,Wu FR,Ge JF,Han WX,Yin CL,Li HJ

更新日期：2014-02-01 00:00:00

abstract：:Radiotherapy and adjuvant cisplatin (DDP) chemotherapy are standard approaches used in the treatment of nasopharyngeal carcinoma (NPC). However, resistance to chemotherapy has recently become more common, resulting in the failure of this combination therapy for NPC. The aim of the present study was to assess the cellu...

journal_title：International journal of molecular medicine

authors： Zhang P,Liu H,Xia F,Zhang QW,Zhang YY,Zhao Q,Chao ZH,Jiang ZW,Jiang CC

更新日期：2014-01-01 00:00:00

abstract：:The low survival rate of patients with colorectal cancer (CRC) is mainly due to the drug resistance of tumor cells to chemotherapeutic agents. It has been reported that basic fibroblast growth factor (bFGF) is an essential factor involved in the epigenetic mechanisms of drug resistance, which provides a novel potentia...

journal_title：International journal of molecular medicine

authors： Luo W,Yu Y,Wang R,He D,Wang C,Zeng X,Chen X,Tan X,Huang T,Wu X

更新日期：2014-01-01 00:00:00

abstract：:New drugs are continuously being developed for the treatment of patients with estrogen receptor-positive breast cancer. Thymoquinone is one of the drugs that exhibits anticancer characteristics based on in vivo and in vitro models. This study further investigates the effects of thymoquinone on human gene expression us...

journal_title：International journal of molecular medicine

authors： Motaghed M,Al-Hassan FM,Hamid SS

更新日期：2014-01-01 00:00:00

abstract：:The tumor microenvironment is thought to affect malignant transformation and tumor progression. The histone methyltransferase, enhancer of zeste homologue 2 (EZH2), has recently been suggested to play a critical role in the tumorigenesis of several types of human cancer. The aim of this study was to investigate the ef...

journal_title：International journal of molecular medicine

authors： Xu L,Deng Q,Pan Y,Peng M,Wang X,Song L,Xiao M,Wang Z

更新日期：2014-01-01 00:00:00

abstract：:The development of new osteoconductive bone substitute materials is expected in medicine. In this study, we attempted to produce new hydroxylapatite (HAP)/collagen (Col) composites using two HAP particles of different sizes and porcine type I collagen. The two HAP particles were either nano-sized (40 nm in average dia...

journal_title：International journal of molecular medicine

authors： Hatakeyama W,Taira M,Chosa N,Kihara H,Ishisaki A,Kondo H

更新日期：2013-12-01 00:00:00

abstract：:It is not clear whether pseudoallergic reactions are caused by similar mechanisms as type I allergic reactions. 3‑Caffeoylquinic acid (chlorogenic acid) is an active ingredient in traditional Chinese medicines used for antibacterial, anti-inflammatory and cholagogic purposes. It is assumed to be the reason for the hig...

journal_title：International journal of molecular medicine

authors： Li Q,Zhao Y,Zheng X,Chen Q,Zhang X

更新日期：2013-12-01 00:00:00

abstract：:The present study aimed to analyze the responses to autophagy in osteoarthritis (OA) and aging chondrocytes in order to elucidate the role of autophagy in the pathogenesis of OA. We used multiple assays to confirm that autophagic activity was downregulated in chondrocytes of aged articular cartilage. Surprisingly, we ...

journal_title：International journal of molecular medicine

authors： Chang J,Wang W,Zhang H,Hu Y,Wang M,Yin Z

更新日期：2013-12-01 00:00:00